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KMID : 0385520110240060460
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Analytical Science & Technology
2011 Volume.24 No. 6 p.460 ~ p.466
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A solid-state NMR study on the activity of an antimicrobial peptide, magainin 2
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Kim Chul
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Abstract
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The activity of an antimicrobial peptide, magainin 2, on lipid membranes was investigated using solid-state NMR and a new sampling method that employed mechanically aligned bilayers between thin glass plates. The experiments were performed at two hydration levels. At 95% hydration about 15% of the lipid bilayers were disrupted and at full hydration 20% were disrupted. From the comparison of two equilibrium states established by two sampling methods the importance of peptide binding to the lipid bilayer for whole membrane disruption was demonstrated.
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KEYWORD
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antimicrobial peptide, lipid bilayer, hydration, solid-state NMR,
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